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Intravenous Solutions

1        Product Description: Infusion therapy supports the restoration and maintenance of physiological conditions of patients referred to as “homeostasis” Which is described as the “physiological equilibrium” of the human organism. There are four main ranges of application of highly specialized intravenous infusion solutions. These are (a) treatment of disturbed water and electrolyte metabolism, especially in severe cases, (b) therapy of acid-base imbalances, (c) volume substitution and volume replacement in surgery of an accident victim suffering blood loss and (d) parental nutrition for severely ill and postoperative patients. Infusion therapy as a basic tool of modern medical care enables physicians to restore and stabilize homeostasis stress quickly and completely.

 

2        Market Potential: For a long time all intravenous solution requirements of the country were being imported to the country were being imported to the country. During the last 10 years one or two plants were established to meet some of the intravenous solutions requirement of the country’s health system. However, due to some technical and financial problems, these new plants have almost ceased operations. Hence a country of 75 million people with an expanding health care system’s till imports all its requirements of intravenous solutions. If we assume that at least one percent of the population require intravenous solution and consumption by each individual patient of the population require intravenous solution and consumption by each individual patient is about liters per year, the annual demand for intravenous solution in the country will be about 1.5 million liters per year. This conservative estimate is more than the production capacity of an intravenous solutions making plant.

 


3        Source of Raw material: Main inputs required for making intravenous solution are chemical (dextrose), PE for plastic bottles, PVC bags with stoppers, glass bottles with stoppers and packaging boxes. The plastic bottles and the packaging boxes can be purchased from domestic sources. Dextrose is made from starch; and the starch could be obtained from the food industries.

 

4        Process and Technology: The main manufacturing/production stages include treatment of water, distillation, preparation of solutions, filling and sealing of bottles, sterilization (by autoclave), visual inspection, labeling and packaging. Water needed for the production of infusion solutions has to be of extremely high quality, which can be achieved only by special purification treatment. The steps needed for the treatment of the water are pre filtration, active carbon filtration, sterile filtration, demineralization via ion exchanger (anion/ cation columns

), de mineralized water storage tank, pre filtration of de mineralized water and sterile filtration of de mineralized water. The distillation unit is fed with fully de mineralized water; the distillate is generated by multi-step  evaporators and subsequent condensation. After condensation, the water is stored at temperature of approx. 90oC. From this storage it is pumped to the various production points by centrifugal pumps. The preparation of the water is followed by the preparation of the intravenous solutions. Typical infusion solutions formula are: 0.9% normal saline in water, 5.0% dextrose in water, 5.0% dextrose in normal saline. The chemicals are controlled by the quality control section prior to the manufacturing process. The preparation of the solutions is followed by filling and sealing of bottles. Then follows sterilization by autoclave. The bottles stacked on the special wagons are rolled in to the autoclave chamber and sterilized in accordance with an electronically controlled cycle having three stages heating, actual sterilization and cooling periods. Subsequent processes are visual inspection, labeling and packaging. Main machinery and equipment needed include demineralization unit, distillation unit, solution preparation unit, autoclave, labeling machine, packaging machine, steam generator, compressed air plant cooling and chilled water plant, and laboratory equipments. 


5        Estimated Investment:- For a plant which can produce 900,000 liters of intravenous solutions per year, the estimated investment will be:

    • Building/shade 3700m2 at Birr 2500/m2 ……..= Birr    9,300,000
    • Machinery and Equipment….……………….. = Birr   21,400,000
    • Working capital ……………………………….= Birr  3,000,000

Total….. = Birr  33,700,000

6          Benefits:  Similar to other projects

          7.Location: Bahir Dar, Debre Birhan


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